A romantic comedy on the backdrop of sperm donation, Vicky Donor's story is about Dr. Baldev Chaddha (Annu Kapoor), a fertility expert, who convinces Vicky to become a donor until he finally gives in. Vicky falls in love with Ashima Roy (Yami Gautam), a Bengali who works in a bank. They get married and the rest of the film is about how Vicky and Ashima deal with him being a sperm donor and how it changes their lives.